PATHWAY interessanti: possibili relazioni con esposizioni ELF

ROS/GSK-3β signaling pathway

diabete, danneggiamento membriana mitocondriale, ruolo nel metabolismo del glucosio. Ruolo della NAC e ATP

GUATIONE E CICLO POLIOLI

Ciclo ossido nitrico no/onoo-

AMPK NRf2

metformina, berberina, melatonina

LITIO e canali del sodio, attività glutamatergica

ADCY2 (gene dell’adenilato ciclasi2)

La adenilato ciclasi o adenilico ciclasi, spesso abbreviata come AC, è un enzima della classe delle liasi che catalizza la seguente reazione:

ATP = AMP 3′,5′-ciclico + pirofosfato

Si tratta di una proteina integrale della membrana plasmatica il cui sito attivo è rivolto verso il citosol della cellula. Fenomeni biologici che sono stati dimostrati dipendere dall’attività delle ACs comprendono:

funzioni cerebrali mediate da neurotrasmettitori;

differenziamento cellulare embrionale;

fenomeni di resistenza alle azioni molecolari dell’insulina;

maturazione degli spermatogoni a spermatozoi;

fenomeni di dipendenza da farmaci e/o droghe;

soppressione di certe funzioni immunitarie.

MAGR/CRY

trasduttore dei campi, bussola aviaria….in cilia???

GNRH/LEPTIN/KISS   e ossido nitrico endometriosi???

relazioni vomeronasal, neurogenesi, iperemia e sistema ipotalamo ipofisi gonadi

GnRH e p450?? Reproductive hormones regulate the selective permeability of the blood-brain barrier a redistribution of the gap junction protein connexin-43 (Cx43)?

p45019A (aromatase) e dopamina nel cervello

activation of microglial NFkB and TNF-α release reduce neurogenesis in aged mice by a decline of hypothalamic GnRH levels.

la melatonina inibisce produzione di GnRH. Le lettine stimolano aromatasi

aromatasi serve a produrre estrogeni da androgeni

Gonadotropin-Releasing Hormone (GnRH) Activates the

M-Current in GnRH Neurons: An Auto-regulatory

Negative Feedback Mechanism? Canali HCN! Hyperpolarization-activated Cyclic Nucleotide-gated Channel)

ZO‐1

protein levels decreased in the rat cerebral

cortex, but increased in the hippocampus 1 h and 3 h

after EMP exposure. EMP‐induced BBB opening within the cerebral

cortex  maybe  related  to decreasing  levels and

altered localization of ZO‐1

SIRTUIN

NUCLEUS COERULEUS NORADRENALIN MONOAMINE

CFOS

Iperosmia: distruzione dei neuroni dopaminergici nel bulbo olfattivo

MTHFR AND DEPRESSION – THE FOLATE AND BH4 CONNECTION

VOMERONASAL MHC

Ruolo della NA e della Vasopressina sull’ipotalamo CRH cortisolo….

SONIC HEDGEHOG e NO olfactory neurogenesis inflammation

CILIA! motile cilia TRPV4 transient receptor potential channel Pkd2l1 (polycystin Proteins related to TRP channels, including TRP-melastatin 5 (TRPM5), polycystic kidney disease-1-like 3 (PKD1L3), and polycystic kidney disease-2-like 1 (PKD2L1), are also expressed in taste cells)

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

TRP obesity.  CSF-contacting neurons (CSFcNs) suggested a sensory function

in the detection of CSF composition

or flow. PKD2L1 is a marker of CSF-cNs

Connexin-43 Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular

alkalinization

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.  CNTF could reduce food intake without causing hunger or stress, CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts) Ciliary neurotrophic factor prevents NO mediated cytotoxicity in cultured hippocampal neurons and reduce food intake

Microtubuli e acquaporine!

Fibroblast growth factor 21, PPARα Peroxisome proliferator-activated receptor alpha (PPAR-alpha also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1)), obesity? Obesity is a fibroblast growth factor 21 (FGF21)-resistant state

Acido ialuronico e polarità cellulare, microtubuli

CSF and regulation of Neural Stem Cells (NSC): NSC sense CSF through a transmembrande sodium Channel (ENaC).

Ceruloplasmin and CSF copper transport.

Metionina /Melatonina e cilia motility (presence of NOS and thiol-based enzymetic system. (Thioredoxin and glutathione)

Intracellulr elevated calcium and ciliary disassembly.  calcium in cilia and TPRV4

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins,

NAT N-acetyltransferase nd nocturnal rise in pineal melatonin synthesis

dynorphine, melatonine and Beta Ebdorphine as equivalent. Role in lowering DA production

LKB1/AMPK

ALCALINIZZAZIONE e  apertura CX43 e influsso Ca2+ (aumento PH diminuzione ioni H+ in scala logaritmica), perdita gradiente protonico apertura delle CX43 uso del lantanide La3+ e apertura TRP, aumento ATP e glutammato astrociti…..trasporto glutatione, NAD+ glucose ePGE2

Wnt signaling pathway  e Hedgehog. Cilia Sound No

PTEN AMPK- COX2 inflammation metformin

effects of ciliary neurotrophic factor (CNTF) and depolarization (sciatic nerve substance P / pineal gland)

Epidermide, TRPV1 e neuropatia delle piccole fibre

Batteri e uso del perossinitrito per legarsi all’ospite.

Magentotassie dei deltaproteobatteri. Magnetospirillum is a Gram-negative, microaerophilic genus of magnetotactic bacterium, CONTRALLARE FERRITINA e magnetosomi nell’uomo